RF-021Original text reviewed
Changed cortical gene expression after a 5G signal
The reported finding
RNA sequencing detected 77 differentially expressed genes in the right sampled cortex and 84 in the left after repeated exposure, using false-discovery-rate correction.
Reading it carefully
Behaviour was not altered. Gene-expression change is a biological response, not demonstrated brain injury. Preprint and journal paper are the same work.
Inside the study
Exposure conditions
5G-modulated 3.5 GHz; one hour/day, five days/week; 27 exposure hours over six weeks for transcriptomics. Whole-brain average SAR 0.19 W/kg.
Design & controls
32 male mice overall; exposed, pseudo-exposed and unrestrained controls. Transcriptomics n=7 exposed and n=8 pseudo-exposed.
Related research & shared cohorts
Distinct French research programme.
The protection question raised
Do the gene-expression changes persist or alter brain function? Behaviour was unchanged. A signal-specific biological response is useful to scientific understanding without establishing injury or measuring population cumulative exposure.
Source verification
Full indexed article body reviewed
Where to find the result
Results RNA sequencing; Figure 1; protocol Figure 2
Editorial notices
Primary PubMed linked-notice record checked 20 Oct 2026; no correction, concern or retraction linked at check. This is not an exhaustive publisher-history certification.
Funding
Crossref publisher-deposited metadata lists French ANSES environmental and occupational health programme grant 2020/2 RF/14. Complete original funding/disclosure statement not rechecked.
Conflicts of interest
Not established from retrieved material.
Original publication
Lameth J, Royer J, Martin A, Marie C, Arnaud-Cormos D, Lévêque P, Poirier R, Edeline JM, Mallat M. Repeated Head Exposures to a 5G-3.5 GHz Signal Do Not Alter Behavior but Modify Intracortical Gene Expression in Adult Male Mice. International Journal of Molecular Sciences. 2025;26(6):2459. doi:10.3390/ijms26062459.