CTX-004Replication and cohort context
Carcinogenicity Study of 217 Hz Pulsed 900 MHz Electromagnetic Fields inPim1Transgenic Mice
The reported finding
Blinded attempted RF-024 replication: 50/sex/group, 0.5/1.4/4 W/kg, one hour/day for 18 months; no tumour-site increase. Tubes restrained animals, unlike original free movement.
Reading it carefully
RF-024 should not be described as independently established. Utteridge 2002 also did not confirm; DOI 10.1667/0033-7587(2002)158[0357:LTEOEP]2.0.CO;2.
Inside the study
Exposure conditions
900 MHz, 217-Hz pulsed fields; whole-body SAR 0.5, 1.4 or 4 W/kg; one hour/day for 18 months.
Design & controls
E-mu-Pim1 transgenic mice; 50 males and 50 females/group, with RF groups versus sham and cage controls. Blinded attempted replication of RF-024. Tubes restrained animals, unlike the original free-movement arrangement.
The protection question raised
Is the original lymphoma signal reproducible in the susceptible model? Differences in restraint and exposure remain relevant, but nonconfirming attempts prevent treating the effect as independently established.
Source verification
Primary PubMed abstract/method summary checked.
Where to find the result
Original abstract, Radiation Research 2007;168(3):316-326; full-method audit incomplete.
Editorial notices
No additional editorial notice established in the retrieved original record.
Funding
Not established from retrieved material.
Conflicts of interest
Not established from retrieved material.
Original publication
Oberto G, Rolfo K, Yu P, Carbonatto M, Peano S, Kuster N, Ebert S, Tofani S. Carcinogenicity Study of 217 Hz Pulsed 900 MHz Electromagnetic Fields inPim1Transgenic Mice. Radiation Research. 2007;168(3):316-326. doi:10.1667/rr0425.1.