Ion-channel disruption, oxidative stress and DNA damage

What this paper brings together

A biophysical and biological synthesis connecting forced oscillation of ions, voltage-gated channels, oxidative stress and DNA damage.

The authors’ synthesis or proposal

Develops an ion forced-oscillation model: polarized low-frequency components may disturb voltage-gated ion channels, change intracellular ions and promote reactive oxygen species and DNA damage.

Reading the connections carefully

Mechanistic synthesis and theoretical modelling; its full causal chain is not established across exposure types or validated as a quantitative predictor of human disease.

Study records to read alongside

These are topical connections within this library. A link does not mean the review cited this particular paper or independently confirmed its result.

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• RF-008 Cell-stage differences plus transient mature-sperm DNA damage and motility loss
• RF-046 Oxidative mitochondrial DNA markers in primary cortical neurons
• RF-005 DNA damage in selected rodent tissues
• RF-016 Different genotoxic responses across human cell types