# WEB-019 — Exploratory gene-expression findings in skin cells at 60.4 GHz

Why this matters
A useful research record also shows how a finding was selected. Five gene responses were confirmed after exploratory screening, while the genome-wide corrected analysis found no significant change.

Id: WEB-019

Author: Le Quément et al.

Full Authors: Catherine Le Quément; Christophe Nicolas Nicolaz; Maxim Zhadobov; Fabienne Desmots; Ronan Sauleau; Marc Aubry; Denis Michel; Yves Le Dréan

Year: 2012

Title: Whole-genome expression analysis in primary human keratinocyte cell cultures exposed to 60 GHz radiation

Journal: Bioelectromagnetics

Citation: Catherine Le Quément; Christophe Nicolas Nicolaz; Maxim Zhadobov; Fabienne Desmots; Ronan Sauleau; Marc Aubry; Denis Michel; Yves Le Dréan. Whole-genome expression analysis in primary human keratinocyte cell cultures exposed to 60 GHz radiation. Bioelectromagnetics. 2012. doi:10.1002/bem.20693.

Doi: 10.1002/bem.20693

Pmid: 21812010

Topic: Skin-cell signalling; 60 GHz-region biological responses

Verification Group: Original abstract reviewed

Record Role: Original abstract reviewed

Featured: False

Exposure: 60.4 GHz; incident density 1.8 mW/cm²; average SAR 42.4 W/kg; 1, 6 or 24 h.

Design: Primary human keratinocyte cultures; microarrays versus sham, followed by PCR of 24 preselected genes.

Finding: PCR confirmed CRIP2, PLXND1, PTX3, SERPINF1 and TRPV2 expression differences at 6 h after exploratory preselection.

Statistics: See reported finding and original tables; effect sizes not independently recalculated.

Boundary: No transcript passed stringent Benjamini–Hochberg genome-wide correction. Abstract-only methods check; exploratory follow-up does not establish a robust transcriptome-wide effect, injury or an oxygen mechanism.

Related:  Later related records: WEB-029. These are different experiments, not necessarily independent replication.

Protection Question: Which exposure conditions and biological models reproduce this response, and what would establish its relevance to health?

Access: Original abstract and bibliographic metadata checked; full methods and dosimetry not audited.

Locator: Original abstract; methods verification incomplete

Notice: Linked notice fields in retrieved Europe PMC/PubMed records checked 21 October 2026; no correction or retraction surfaced there. Publisher-history and forward-citation screening are not exhaustive.

Funding: Not established from retrieved original abstract.

Conflicts: Not established from retrieved original abstract.

Source Url: https://doi.org/10.1002/bem.20693

Retrieval Links: https://doi.org/10.1002/bem.20693 | https://pubmed.ncbi.nlm.nih.gov/21812010/

Verification Date: 2026-10-21

Discovery Id: EML-WIGIG-002

Technology Tracks: wigig|millimetre

Technology Connection: 60 GHz-region experiment; not a test of a WiGig device or an oxygen-deprivation mechanism.

Publication Type: Original journal research

Study Setting: Cells / isolated tissue

Browse Categories: cells