# WEB-013 — Gene-expression and growth changes in tumour organoids at 30.5 GHz

Why this matters
Three-dimensional tissue models can reveal biological responses missed by simpler assays. This study examines millimetre waves in tumour tissue, with that therapeutic context kept explicit.

Id: WEB-013

Author: Rampazzo et al.

Full Authors: Elena Rampazzo; Luca Persano; Nissar Karim; George Hodgking; Rosanna Pinto; Arianna Casciati; Mirella Tanori; Alessandro Zambotti; Silvia Bresolin; Alice Cani; Alessandro Pannicelli; Ilan W Davies; Cristopher Hancock; Cristiano Palego; Giampietro Viola; Mariateresa Mancuso; Caterina Merla

Year: 2024

Title: On the effects of 30.5 GHz sinusoidal wave exposure on glioblastoma organoids

Journal: Frontiers in oncology

Citation: Elena Rampazzo; Luca Persano; Nissar Karim; George Hodgking; Rosanna Pinto; Arianna Casciati; Mirella Tanori; Alessandro Zambotti; Silvia Bresolin; Alice Cani; Alessandro Pannicelli; Ilan W Davies; Cristopher Hancock; Cristiano Palego; Giampietro Viola; Mariateresa Mancuso; Caterina Merla. On the effects of 30.5 GHz sinusoidal wave exposure on glioblastoma organoids. Frontiers in oncology. 2024. doi:10.3389/fonc.2024.1307516.

Doi: 10.3389/fonc.2024.1307516

Pmid: 38884089

Topic: Tumour-organoid responses; Millimetre-wave cellular responses

Verification Group: Original text reviewed

Record Role: Original text reviewed

Featured: False

Exposure: 30.5 GHz continuous wave; 0.1 W RMS for 20 min or 0.2 W for 10 min; temperature monitored and modelled. Generator power is not tissue SAR.

Design: Patient-derived glioblastoma organoids from three specimens; sham comparisons; molecular, proliferation/apoptosis and temozolomide-response assays.

Finding: Gene expression, proliferation and selected apoptosis measures changed; one exposure condition increased the response to temozolomide.

Statistics: See reported finding and original tables; effect sizes not independently recalculated.

Boundary: Tumour and therapeutic model; not healthy-tissue toxicity or a cancer-induction experiment. Limited donor material. Preserved differentiation markers and thermal/dosimetry context matter.

Protection Question: Which exposure conditions and biological models reproduce this response, and what would establish its relevance to health?

Access: Original methods/results sections reviewed; no independent raw-data or supplement audit.

Locator: Original results/methods sections

Notice: Linked notice fields in retrieved Europe PMC/PubMed records checked 21 October 2026; no correction or retraction surfaced there. Publisher-history and forward-citation screening are not exhaustive.

Funding: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Project ECS 0000024 Rome Technopole, -CUP B83C22002820006, NRP Mission 4 Component 2 Investment 1.5, Funded by the European Union -NextGenerationEU. AC was supported by fellowships from the Umberto Veronesi Foundation (#4420, #4820 and #5216).

Conflicts: Conflict of interest Authors GH, ID, and CH were employed by the company CREO Medical Limited. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Source Url: https://doi.org/10.3389/fonc.2024.1307516

Retrieval Links: https://doi.org/10.3389/fonc.2024.1307516 | https://pubmed.ncbi.nlm.nih.gov/38884089/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11176452/

Verification Date: 2026-10-21

Discovery Id: EML-MMW-003

Technology Tracks: millimetre|5g

Technology Connection: Millimetre-wave laboratory biology; frequency overlap does not demonstrate effects from a deployed system.

Publication Type: Original journal research

Study Setting: Cells / isolated tissue

Browse Categories: cancer|cells