# RF-051 — Follow-up acute microwave DNA strand-break experiment

Why this matters
A follow-up reported breaks affecting one or both strands of DNA in rat brain cells after exposure. It broadens the laboratory endpoint examined in RF-050 , while remaining part of the same research programme. Full assay controls and replication history remain necessary before treating this as confirmed injury.

Id: RF-051

Author: Lai and Singh

Full Authors: Henry Lai; Narendra P Singh

Year: 1996

Title: Single- and double-strand DNA breaks in rat brain cells after acute exposure to radiofrequency electromagnetic radiation

Journal: International Journal of Radiation Biology

Citation: Lai H, Singh NP. Single- and double-strand DNA breaks in rat brain cells after acute exposure to radiofrequency electromagnetic radiation. Int J Radiat Biol. 1996;69(4):513-521. doi:10.1080/095530096145814.

Doi: 10.1080/095530096145814

Pmid: 8627134

Topic: DNA and cell responses

Verification Group: Original abstract verified

Record Role: Original abstract verified methods pending

Featured: False

Exposure: 2450 MHz pulsed (2 microseconds, 500/s) or continuous-wave; two hours; spatial-average incident power density 2 mW/cm2 and whole-body SAR 1.2 W/kg.

Design: Rat-brain microgel electrophoresis at four hours post-exposure; original abstract checked; exact n and assay quality-control procedures pending.

Finding: Original abstract reports increased single- and double-strand breaks after either signal, with no significant difference between pulsed and continuous-wave effects.

Boundary: Mechanistic research lead; full methods and conflicting replication protocols require comparison before a causal generalisation. Whole-body animal exposure does not establish below-limit human injury.

Related: Same programme as RF-050; count the publications separately from independent laboratories.

Protection Question: Are the reported strand-break findings reproducible across comparable assays and exposure conditions? Related investigators and unresolved replication differences limit a general mechanism or human protection inference.

Access: Scite original abstract and metadata verified

Locator: Original abstract; pp.513-521 methods pending

Notice: No notice surfaced in Scite or targeted title/DOI search; not a complete status certification.

Funding: Not established from retrieved material.

Conflicts: Not established from retrieved material.

Source Url: https://doi.org/10.1080/095530096145814

Retrieval Links: https://doi.org/10.1080/095530096145814 | https://pubmed.ncbi.nlm.nih.gov/8627134/

Verification Date: 2026-10-20