# RF-042 — 3.5 GHz skin-cell/UV-B mitochondrial response

Why this matters
Skin cells encounter more than one stressor. This study's abstract reports that a 5G signal changed some chemical responses involving ultraviolet light, with different patterns in different cell types. The finding makes combined exposures worth examining; full methods and functional consequences must be checked before drawing a health-protection conclusion.

Id: RF-042

Author: Patrignoni et al.

Full Authors: Lorenza Patrignoni; Annabelle Hurtier; Rosa Orlacchio; Alexandre Joushomme; Florence Poulletier de Gannes; Philippe Lévêque; Delia Arnaud-Cormos; Hamid Reza Revzani; Walid Mahfouf; André Garenne; Yann Percherancier; Isabelle Lagroye

Year: 2024

Title: Evaluation of mitochondrial stress following ultraviolet radiation and 5G radiofrequency field exposure in human skin cells

Journal: Bioelectromagnetics

Citation: Lorenza Patrignoni; Annabelle Hurtier; Rosa Orlacchio; Alexandre Joushomme; Florence Poulletier de Gannes; Philippe Lévêque; Delia Arnaud-Cormos; Hamid Reza Revzani; Walid Mahfouf; André Garenne; Yann Percherancier; Isabelle Lagroye. Evaluation of mitochondrial stress following ultraviolet radiation and 5G radiofrequency field exposure in human skin cells. Bioelectromagnetics. 2024;45(3):110-129. doi:10.1002/bem.22495.

Doi: 10.1002/bem.22495

Pmid: 38115173

Topic: Newer signals and co-stressors

Verification Group: Original abstract verified

Record Role: Original abstract verified

Featured: False

Exposure: 5G-modulated 3.5 GHz at 0.25,1 or 4 W/kg for 24 h in fibroblasts/keratinocytes, including UV-B co-exposure.

Design: Original in-vitro experiment; full methods, independent replicate counts and temperature controls remain to retrieve.

Finding: Abstract reports reduced mitochondrial ROS in fibroblasts at 1 W/kg and enhanced UV-B-related ROS in keratinocytes at 0.25 and 1 W/kg. No membrane-potential or apoptosis effect.

Boundary: A biochemical response, not demonstrated injury. No independently checked effect size or complete protocol; exclude from central claims.

Related: Bordeaux/Limoges skin-cell programme. Haidar 2025, DOI10.1038/s41598-025-15090-w, uses different ROS biosensors and is not an exact independent replication.

Protection Question: Could RF modify a skin-cell response to ultraviolet exposure? Different cell responses and absent measured apoptosis leave this a biochemical co-stressor hypothesis; full methods and functional consequences remain unverified.

Access: Primary publisher abstract and first PDF page reviewed; Scite abstract only. Retrieval lead.

Locator: Abstract; publisher PDF first page 110.

Notice: No editorial notice surfaced in the Scite/primary-record checks used for this record; this is not a comprehensive clean-bill certification.

Funding: ANSES2019/2RF/018; New Aquitaine AAPR2020A-2019-8140010, as listed on original PDF first page.

Conflicts: Not established from retrieved material.

Source Url: https://doi.org/10.1002/bem.22495

Retrieval Links: https://doi.org/10.1002/bem.22495 | https://pubmed.ncbi.nlm.nih.gov/38115173/

Verification Date: 2026-10-20

Technology Tracks: 5g