# REV-022 — Pall’s proposed EMF–calcium–Alzheimer’s pathway

Collection: Reviews & proposed mechanisms (not an original experiment)

Id: REV-022

Heading: Pall’s proposed EMF–calcium–Alzheimer’s pathway

Doi: 10.2174/1567205019666220202114510

Title: Low Intensity Electromagnetic Fields Act via Voltage-Gated Calcium Channel (VGCC) Activation to Cause Very Early Onset Alzheimer's Disease: 18 Distinct Types of Evidence

Authors: Martin L Pall

Author: Pall

Date: 2022-03-11

Kind: Proposed mechanism

Why: Calcium regulation is important in the biology of Alzheimer’s disease. Pall brings that research together with EMF findings to propose a pathway linking exposure, cellular stress and neurodegeneration.

Scope: A mechanistic mini-review relating calcium-dependent processes in Alzheimer’s disease to laboratory and epidemiological EMF literature.

Summary: Pall organises 18 lines of argument around calcium-channel activation, oxidative/nitrosative stress, inflammation and amyloid-related processes. He proposes that pulsed exposures could contribute to earlier neurodegeneration.

Limitations: The synthesis does not establish that everyday wireless use causes Alzheimer’s disease or predict an age of onset. Animal neurodegeneration, human diagnoses and exposure regimes are distinct; the paper itself calls for better epidemiology and biomarker studies.

Topics: Calcium signalling; Neurodegeneration; Oxidative stress

Exposures: Radiofrequency; ELF magnetic fields; Modulated wireless signals

Journal: Current Alzheimer research

Links: https://doi.org/10.2174/1567205019666220202114510; https://pubmed.ncbi.nlm.nih.gov/35114921/; https://pmc.ncbi.nlm.nih.gov/articles/PMC9189734/

Access Label: Original-text passages checked

Source Check: Primary metadata, abstract and selected original-text discussion/conclusion passages checked. Linked notice records checked on 21 October 2026. The publisher gives 11 March 2022 as publication date; the PMC issue record is dated 27 April 2022.

Citation: Martin L Pall. Low Intensity Electromagnetic Fields Act via Voltage-Gated Calcium Channel (VGCC) Activation to Cause Very Early Onset Alzheimer's Disease: 18 Distinct Types of Evidence. Current Alzheimer research. 2022. doi:10.2174/1567205019666220202114510.

Related Studies: RF-020; RF-034; WEB-055; RF-029; ELF-005

Url: /reviews/rev-022/

Year: 2022

Record Type: review_or_mechanism

Source Url: https://doi.org/10.2174/1567205019666220202114510