# REV-021 — Pall’s calcium-signalling model of autism development

Collection: Reviews & proposed mechanisms (not an original experiment)

Id: REV-021

Heading: Pall’s calcium-signalling model of autism development

Doi: 10.3390/brainsci14050454

Title: Central Causation of Autism/ASDs via Excessive [Ca2+]i Impacting Six Mechanisms Controlling Synaptogenesis during the Perinatal Period: The Role of Electromagnetic Fields and Chemicals and the NO/ONOO(-) Cycle, as Well as Specific Mutations

Authors: Martin L Pall

Author: Pall

Date: 2024-04-30

Kind: Proposed mechanism

Why: Early brain development depends on precisely regulated signals between cells. This paper asks whether disturbed calcium signalling could connect environmental exposures with altered synapse formation.

Scope: Connects perinatal synapse development, intracellular calcium, genetic findings, chemicals and EMF exposure in a single explanatory model.

Summary: Pall argues that excessive intracellular calcium can disturb six mechanisms controlling synapse formation, and proposes VGCC activation as the EMF-related entry point. He also invokes oxidative/nitrosative cycles and epigenetic dysfunction.

Limitations: This is a literature-based causal proposal, not a prospective study establishing that wireless exposure causes autism. Connections drawn from different models and exposures need direct validation. The paper’s prevention and treatment suggestions are not established by this synthesis.

Topics: Calcium signalling; Neurodevelopment; Oxidative stress

Exposures: Radiofrequency; ELF magnetic fields; Modulated wireless signals

Journal: Brain sciences

Links: https://doi.org/10.3390/brainsci14050454; https://pubmed.ncbi.nlm.nih.gov/38790433/; https://pmc.ncbi.nlm.nih.gov/articles/PMC11119459/

Access Label: Original-text passages checked

Source Check: Primary metadata, abstract and selected original-text discussion/conclusion passages checked. Linked notice records checked on 21 October 2026.

Citation: Martin L Pall. Central Causation of Autism/ASDs via Excessive [Ca2+]i Impacting Six Mechanisms Controlling Synaptogenesis during the Perinatal Period: The Role of Electromagnetic Fields and Chemicals and the NO/ONOO(-) Cycle, as Well as Specific Mutations. Brain sciences. 2024. doi:10.3390/brainsci14050454.

Related Studies: RF-020; RF-034; WEB-055; RF-036; RF-041

Url: /reviews/rev-021/

Year: 2024

Record Type: review_or_mechanism

Source Url: https://doi.org/10.3390/brainsci14050454