# REV-005 — NADPH oxidase as a possible link between fields and oxidative stress

Collection: Reviews & proposed mechanisms (not an original experiment)

Doi: 10.3390/ijms221810041

Title: Oxidative Stress and NADPH Oxidase: Connecting Electromagnetic Fields, Cation Channels and Biological Effects

Authors: Christos D Georgiou; Lukas H Margaritis

Date: 2021-09-17

Issueyear: 2021

Why: This paper asks how an exposure might engage the cell’s own machinery for generating reactive molecules.

Summary: Reviews a proposed route from EMF-sensitive cation channels to NADPH oxidase activation and oxidative stress, discussing downstream damage to DNA and other cell components.

Limitations: Biochemical plausibility and synthesis, not direct proof of the complete exposure-to-disease pathway. Authors call for specific in-vivo radical measurements.

Scope: A mechanistic synthesis linking cation-channel regulation, NADPH oxidase activation and reactive oxygen production.

Exposures: ELF magnetic fields; Radiofrequency

Journal: International journal of molecular sciences

Heading: NADPH oxidase as a possible link between fields and oxidative stress

Id: REV-005

Kind: Proposed mechanism

Topics: Oxidative stress; Ion channels; DNA damage

Links: https://doi.org/10.3390/ijms221810041; https://pubmed.ncbi.nlm.nih.gov/34576203/; https://pmc.ncbi.nlm.nih.gov/articles/PMC8470280/

Author: Georgiou et al.

Access Label: Original-text passages checked

Source Check: Full text: introduction and conclusion/limitations passages checked; metadata/abstract also checked. Linked PubMed/Europe PMC notice records checked on 21 October 2026; this is not a guarantee that every editorial update is indexed.

Citation: Christos D Georgiou; Lukas H Margaritis. Oxidative Stress and NADPH Oxidase: Connecting Electromagnetic Fields, Cation Channels and Biological Effects. International journal of molecular sciences. 2021. doi:10.3390/ijms221810041.

Related Studies: RF-006; RF-008; RF-046; RF-005; RF-016

Url: /reviews/rev-005/

Year: 2021

Record Type: review_or_mechanism

Source Url: https://doi.org/10.3390/ijms221810041