# REV-003 — Connecting wireless signals, ion channels and oxidative pathways

Collection: Reviews & proposed mechanisms (not an original experiment)

Doi: 10.3389/fpubh.2025.1585441

Title: A comprehensive mechanism of biological and health effects of anthropogenic extremely low frequency and wireless communication electromagnetic fields

Authors: Dimitris J Panagopoulos; Igor Yakymenko; Geoffry N De Iuliis; George P Chrousos

Date: 2025-06-04

Issueyear: 2025

Why: This later synthesis connects the physical signal, cell-membrane response and oxidative pathways in one testable framework.

Summary: Extends the ion forced-oscillation/voltage-gated ion-channel hypothesis to wireless carrier signals and their ELF/ULF modulation, linking disturbed ionic regulation to mitochondrial and enzyme-generated oxidative stress.

Limitations: An explanatory proposal built from heterogeneous earlier studies. Authors acknowledge that details connecting ionic perturbations to ROS production need further exploration.

Scope: A 2025 synthesis of laboratory and epidemiological literature proposing an ion-channel-to-oxidative-stress pathway for ELF and wireless exposures.

Exposures: ELF magnetic fields; Radiofrequency; Modulated wireless signals

Journal: Frontiers in public health

Heading: Connecting wireless signals, ion channels and oxidative pathways

Id: REV-003

Kind: Proposed mechanism

Topics: Ion channels; Oxidative stress; DNA damage

Links: https://doi.org/10.3389/fpubh.2025.1585441; https://pubmed.ncbi.nlm.nih.gov/40547468/; https://pmc.ncbi.nlm.nih.gov/articles/PMC12179773/

Author: Panagopoulos et al.

Access Label: Original-text passages checked

Source Check: Full text: introduction and conclusion/limitations passages checked; metadata/abstract also checked. Linked PubMed/Europe PMC notice records checked on 21 October 2026; this is not a guarantee that every editorial update is indexed.

Notices: The publisher records an update on 6 June 2025, two days after first publication. Read the current publisher version.

Notice Urls: https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1585441/full

Citation: Dimitris J Panagopoulos; Igor Yakymenko; Geoffry N De Iuliis; George P Chrousos. A comprehensive mechanism of biological and health effects of anthropogenic extremely low frequency and wireless communication electromagnetic fields. Frontiers in public health. 2025. doi:10.3389/fpubh.2025.1585441.

Related Studies: RF-006; RF-008; RF-046; RF-005; RF-016

Url: /reviews/rev-003/

Year: 2025

Record Type: review_or_mechanism

Source Url: https://doi.org/10.3389/fpubh.2025.1585441